Nuclear bodies: multifaceted subdomains of the interchromatin space

Authors
Citation
Ag. Matera, Nuclear bodies: multifaceted subdomains of the interchromatin space, TR CELL BIO, 9(8), 1999, pp. 302-309
Citations number
61
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
TRENDS IN CELL BIOLOGY
ISSN journal
0962-8924 → ACNP
Volume
9
Issue
8
Year of publication
1999
Pages
302 - 309
Database
ISI
SICI code
0962-8924(199908)9:8<302:NBMSOT>2.0.ZU;2-8
Abstract
Higher-eukaryotic nuclei contain numerous morphologically distinct substruc tures that are collectively called nuclear bodies. Although the precise fun ctions of these subdomains remain unknown elucidation of their molecular co mposition has been the subject of a great deal of research in recent years. Changes in the constitution of these nuclear inclusions are associated wit h disease phenotypes. The wide variety of components that concentrate withi n these subdomains makes them a likely interface for multiple cellular proc esses, including transcription, RNA processing, transport, RNP assembly, pr otein modification apoptosis and cell-cycle control, This review discusses the different types of nuclear bodies, with emphasis on the two most promin ent subtypes - the coiled and PML bodies.