The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum

Citation
S. Bowman et al., The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum, NATURE, 400(6744), 1999, pp. 532-538
Citations number
45
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Multidisciplinary,Multidisciplinary,Multidisciplinary
Journal title
NATURE
ISSN journal
0028-0836 → ACNP
Volume
400
Issue
6744
Year of publication
1999
Pages
532 - 538
Database
ISI
SICI code
0028-0836(19990805)400:6744<532:TCNSOC>2.0.ZU;2-H
Abstract
Analysis of Plasmodium falciparum chromosome 3, and comparison with chromos ome 2, highlights novel features of chromosome organization and gene struct ure. The sub-telomeric regions of chromosome 3 show a conserved order of fe atures, including repetitive DNA sequences, members of multigene families i nvolved in pathogenesis and antigenic variation, a number of conserved pseu dogenes, and several genes of unknown function. A putative centromere has b een identified that has a core region of about 2 kilobases with an extremel y high (adenine + thymidine) composition and arrays of tandem repeats. We h ave predicted 215 protein-coding genes and two transfer RNA genes In the 1, 060,106-base-pair chromosome sequence. The predicted protein-coding genes c an be divided into three main classes: 52.6% are not spliced, 45.1% have a large exon with short additional 5' or 3' exons, and 2.3% have a multiple e xon structure more typical of higher eukaryotes.