Efficacy and cost effectiveness of lansoprazole versus omeprazole in maintenance treatment of symptomatic gastroesophageal reflux disease

Citation
E. Vivian et al., Efficacy and cost effectiveness of lansoprazole versus omeprazole in maintenance treatment of symptomatic gastroesophageal reflux disease, AM J M CARE, 5(7), 1999, pp. 881-886
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Public Health & Health Care Science","Health Care Sciences & Services
Journal title
AMERICAN JOURNAL OF MANAGED CARE
ISSN journal
1088-0224 → ACNP
Volume
5
Issue
7
Year of publication
1999
Pages
881 - 886
Database
ISI
SICI code
1088-0224(199907)5:7<881:EACEOL>2.0.ZU;2-N
Abstract
Objective: To determine the dosing equivalents and cost effectiveness of la nsoprazole versus omeprazole in maintenance therapy of gastroesophageal ref lux disease (GERD). Study Design: Single-blind, randomized, crossover study. Patients and Methods: After completing a 1-week washout period, 27 outpatie nts (mean age, 66 years) with documented GERD were randomly assigned to rec eive omeprazole 20 mg or lansoprazole 15 mg daily for 2 weeks. The dosages were then increased to omeprazole 40 mg or lansoprazole 30 mg daily for an additional 2 weeks. All patients completed a second 1-week washout period b efore crossing over to the alternate agent. Patients recorded GERD-related symptoms (heartburn, chest pain, and regurgitation) daily in a diary. The t otal symptom score (the sum of the 3 individual symptom scores) were compar ed for all treatments. Cost effectiveness was evaluated by determining the cost per percent reduction in the total symptom score. Results: All treatment groups had significant reductions from baseline in t he total symptom score (P < 0.01), No significant difference was seen betwe en lansoprazole 15-mg and omeprazole 20-mg groups or the the lansoprazole 3 0-mg and omeprazole 40-mg groups. Lansoprazole 15 mg was found to be as eff ective as omeprazole 40 mg and omeprazole 20 mg was as effective as lansopr azole 30 mg. The average cost per percent reduction in total symptom score was $0.03 for the lansoprazole 15-mg, lansoprazole 30-mg, and omeprazole 20 -mg doses and $0.05 for the omeprazole 40-mg dose. Conclusion: Lansoprazole is as effective as omeprazole in providing symptom atic relief of GERD, Based on acquisition cost, lansoprazole is more cost e ffective than omeprazole.