Complexes of group 12 metals with 2-acetylpyridine N-4-dimethylthiosemicarbazone and with 2-acetylpyridine-N-oxide N-4-dimethylthiosemicarbazone: Synthesis, structure and antifungal activity

Citation
E. Bermejo et al., Complexes of group 12 metals with 2-acetylpyridine N-4-dimethylthiosemicarbazone and with 2-acetylpyridine-N-oxide N-4-dimethylthiosemicarbazone: Synthesis, structure and antifungal activity, Z NATURFO B, 54(6), 1999, pp. 777-787
Citations number
50
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry
Journal title
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES
ISSN journal
0932-0776 → ACNP
Volume
54
Issue
6
Year of publication
1999
Pages
777 - 787
Database
ISI
SICI code
0932-0776(199906)54:6<777:COG1MW>2.0.ZU;2-2
Abstract
Reaction in ethanol of group 12 metal halides with 2-acetylpyridine N-4-dim ethylthiosemicarbazone (H4DML) and with 2-acetylpyridine-N-oxide N-4-dimeth ylthiosemicarbazone (H4DMLO) afforded complexes of the forms [M(H4DML)X-2] (1 - 9) and [M(H4DMLO)X-2] (10 - 18) (M = Zn-II, Cd-II or Hg-II; X = Cl. Br or I). H4DMLO and the complexes of both thiosemicarbazones have been chara cterized by elemental analysis and by IR and H-1, C-13 and Cd-113 NMR spect roscopy, and the crystal structures of [Cd(H4DML)Cl-2] (4), [Cd(H4DML)I-2] (6), H4DMLO, [HE(H4DMLO)Cl-2] (16) and [Hg(H4DMLO)Br-2] (17) have been dete rmined by X-ray diffractometry. In all the H4DML complexes, the thiosemicar bazone acts as an N,N,S-tridentate ligand, and the coordination polyhedra o f the pentacoordinate metals are more or less distorted tetragonal pyramids . H4DMLO is an O,N,S-tridentate ligand for zinc and cadmium halides and an N,S-bidentate ligand for mercury halides, in which the mercury atom has coo rdination number four and a distorted trigonal pyramidal environment. In as says of antifungal activity against Aspergillus niger and Paecilomyces vari otii, H4DML was more active than nystatin, and its complex with ZnCl2 also showed good activity against A. niger; neither H4DMLO nor any of its comple xes inhibited the growth of either pathogen.