High expression of multidrug resistance-1 (MDR-1) and its relationship with multiple prognostic factors in gastric carcinomas in patients in turkey

Citation
S. Gurel et al., High expression of multidrug resistance-1 (MDR-1) and its relationship with multiple prognostic factors in gastric carcinomas in patients in turkey, J INT MED R, 27(2), 1999, pp. 79-84
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
ISSN journal
0300-0605 → ACNP
Volume
27
Issue
2
Year of publication
1999
Pages
79 - 84
Database
ISI
SICI code
0300-0605(199903/04)27:2<79:HEOMR(>2.0.ZU;2-V
Abstract
Drug resistance remains a major problem in the treatment of gastric cancer. In Turkey, gastric carcinoma is the second most common cancer and, because the rate of early diagnosis is low, chemotherapy plays an important role i n the treatment of the disease. We aimed to investigate expression of the m ultidrug resistance-1 gene (MDR-1) and its relationship with multiple progn ostic factors in gastric cancers. Between 1996 and 1998, a total of 55 pati ents (37 men and 19 women; median age 55 years) were studied. Sections from specimens of gastric carcinomas were immunohistochemically stained to dete ct P-glycoprotein (which is associated with MDR-1 expression). We found MDR -1 expression in 48 (87%) of the patients. None of the multiple prognostic factors, including histological type of tumour, correlated with expression of MDR-1. Patients who had low MDR-1 expression had better survival. We con clude that the expression of MDR-1 in gastric cancer is high in Turkey, and this may be related to poor prognosis.