S. Gurel et al., High expression of multidrug resistance-1 (MDR-1) and its relationship with multiple prognostic factors in gastric carcinomas in patients in turkey, J INT MED R, 27(2), 1999, pp. 79-84
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Drug resistance remains a major problem in the treatment of gastric cancer.
In Turkey, gastric carcinoma is the second most common cancer and, because
the rate of early diagnosis is low, chemotherapy plays an important role i
n the treatment of the disease. We aimed to investigate expression of the m
ultidrug resistance-1 gene (MDR-1) and its relationship with multiple progn
ostic factors in gastric cancers. Between 1996 and 1998, a total of 55 pati
ents (37 men and 19 women; median age 55 years) were studied. Sections from
specimens of gastric carcinomas were immunohistochemically stained to dete
ct P-glycoprotein (which is associated with MDR-1 expression). We found MDR
-1 expression in 48 (87%) of the patients. None of the multiple prognostic
factors, including histological type of tumour, correlated with expression
of MDR-1. Patients who had low MDR-1 expression had better survival. We con
clude that the expression of MDR-1 in gastric cancer is high in Turkey, and
this may be related to poor prognosis.