Dopamine and DOPA cause release of iron from ferritin and lipid peroxidation of liposomes

Citation
M. Tanaka et al., Dopamine and DOPA cause release of iron from ferritin and lipid peroxidation of liposomes, NEUROREPORT, 10(9), 1999, pp. 1883-1887
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
0959-4965 → ACNP
Volume
10
Issue
9
Year of publication
1999
Pages
1883 - 1887
Database
ISI
SICI code
0959-4965(19990623)10:9<1883:DADCRO>2.0.ZU;2-S
Abstract
WE investigated dopamine (DA)- and DOPA-related release of iron from ferrit in, and lipid peroxidation of liposomes induced by the released iron. Iron release increased with increasing DA or DOPA concentrations. Effects of SOD and an oxygen-reduced environment indicated that superoxide was partly res ponsible for iron release. The released iron induced lipid peroxidation at relatively low concentrations of DA or DOPA, while at high concentrations, peroxidation was inhibited. These findings indicate that the risk df lipid peroxidation depends on the DA/iron or DOPA/iron ratio even if the iron con centration is low. Our findings suggest that DA-containing neurons are alwa ys at risk of oxidative damage. Furthermore, DOPA therapy may modify the ni gral degeneration by reducing or accelerating ferritin iron-dependent lipid peroxidation. NeuroReport 10:1883-1887 (C) 1999 Lippincott Williams & Wilk ins.