APOLIPOPROTEIN-E GENOTYPE IN SCHIZOPHRENIA - FREQUENCY, AGE-OF-ONSET,AND NEUROPATHOLOGIC FEATURES

Citation
Se. Arnold et al., APOLIPOPROTEIN-E GENOTYPE IN SCHIZOPHRENIA - FREQUENCY, AGE-OF-ONSET,AND NEUROPATHOLOGIC FEATURES, NeuroReport, 8(6), 1997, pp. 1523-1526
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0959-4965
Volume
8
Issue
6
Year of publication
1997
Pages
1523 - 1526
Database
ISI
SICI code
0959-4965(1997)8:6<1523:AGIS-F>2.0.ZU;2-7
Abstract
Apolipoprotein E (ApoE) genotype has been found to affect the expressi on of a variety of neuropsychiatric disorders. We determined ApoE geno type frequencies and their relationship to clinical and pathological f eatures in a diverse cohort of individuals with schizophrenia. There w ere no differences in ApoE genotype frequencies between schizophrenics and controls. However, the ApoE epsilon 4 genotype was associated wit h a younger age of onset of schizophrenia, and in an elderly subsample , individuals with the epsilon 4 allele more frequently exhibited co-e xistent dementia and had more neurofibrillary pathology (although none of the cases met criteria for Alzheimer's disease). This examination of ApoE in relation to clinical and neurobiological features of schizo phrenia suggests that it modifies the phenotypic expression of the dis ease.