A radionuclide therapy treatment planning and dose estimation system

Citation
A. Liu et al., A radionuclide therapy treatment planning and dose estimation system, J NUCL MED, 40(7), 1999, pp. 1151-1153
Citations number
5
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
JOURNAL OF NUCLEAR MEDICINE
ISSN journal
0161-5505 → ACNP
Volume
40
Issue
7
Year of publication
1999
Pages
1151 - 1153
Database
ISI
SICI code
0161-5505(199907)40:7<1151:ARTTPA>2.0.ZU;2-G
Abstract
An object-oriented software system is described for estimating internal emi tter absorbed doses using a set of computer modules operating within a pers onal computer environment. The system is called the Radionuclide Treatment Planning and Absorbed Dose Estimation System (RTDS). It is intended for rad ioimmunotherapy applications, although other forms of internal emitter ther apy may also be considered. Methods: Four software modules interact through a database backend. Clinical, demographic and image data are directly ente red into the database. Modules include those devoted to clinical imaging (n uclear, CT and MR), activity determination, organ compartmental modeling an d absorbed dose estimation. Results: Both standard phantom (Medical Interna l Radiation Dose [MIRD]) and patient-specific absorbed doses are estimated. All modules interact with the database backend so that changes in one proc ess do not influence other operations. Results of the modular operations ar e written to the database as computations are completed. Dose-volume histog rams are an intrinsic part of the output for patient-specific absorbed dose estimates. A sample dose estimate for a potential Y-90 monoclonal antibody is described. Conclusion: A four-module software system has been implement ed to estimate MIRD phantom and patient-specific absorbed doses. Computatio ns of the doses and their statistical distribution for a pure beta emitter such as Y-90 take approximately 1 min on a 300 MHz personal computer.