A radionuclide therapy treatment planning and dose estimation system

Liu, A Williams, LE Lopatin, G Yamauchi, DM Wong, JYC Raubitschek, AA

A. Liu et al., A radionuclide therapy treatment planning and dose estimation system, J NUCL MED, 40(7), 1999, pp. 1151-1153

5

INGLESE

Article

Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment

JOURNAL OF NUCLEAR MEDICINE

0161-5505 → ACNP

40

7

1999

1151 - 1153

ISI

0161-5505(199907)40:7<1151:ARTTPA>2.0.ZU;2-G

An object-oriented software system is described for estimating internal emi tter absorbed doses using a set of computer modules operating within a pers onal computer environment. The system is called the Radionuclide Treatment Planning and Absorbed Dose Estimation System (RTDS). It is intended for rad ioimmunotherapy applications, although other forms of internal emitter ther apy may also be considered. Methods: Four software modules interact through a database backend. Clinical, demographic and image data are directly ente red into the database. Modules include those devoted to clinical imaging (n uclear, CT and MR), activity determination, organ compartmental modeling an d absorbed dose estimation. Results: Both standard phantom (Medical Interna l Radiation Dose [MIRD]) and patient-specific absorbed doses are estimated. All modules interact with the database backend so that changes in one proc ess do not influence other operations. Results of the modular operations ar e written to the database as computations are completed. Dose-volume histog rams are an intrinsic part of the output for patient-specific absorbed dose estimates. A sample dose estimate for a potential Y-90 monoclonal antibody is described. Conclusion: A four-module software system has been implement ed to estimate MIRD phantom and patient-specific absorbed doses. Computatio ns of the doses and their statistical distribution for a pure beta emitter such as Y-90 take approximately 1 min on a 300 MHz personal computer.