Resorption kinetics of four hydroxyapatite-based ceramics by particle induced X-ray emission and neutron activation analysis

Citation
E. Jallot et al., Resorption kinetics of four hydroxyapatite-based ceramics by particle induced X-ray emission and neutron activation analysis, EPJ-APPL PH, 6(2), 1999, pp. 205-215
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Apllied Physucs/Condensed Matter/Materiales Science
Journal title
EUROPEAN PHYSICAL JOURNAL-APPLIED PHYSICS
ISSN journal
1286-0042 → ACNP
Volume
6
Issue
2
Year of publication
1999
Pages
205 - 215
Database
ISI
SICI code
1286-0042(199905)6:2<205:RKOFHC>2.0.ZU;2-4
Abstract
From the viewpoint of hard tissue response to implant materials, calcium ph osphates are probably the most compatible materials presently known. During the last few years, much attention has been paid to hydroxyapatite and bet a-tricalcium phosphate as potential biomaterials for bone substitute. A goo d implantation of biomaterials in the skeleton is to reach full integration of non-living implant with living bone. The aim of this study is to compar e the resorption kinetics of four kinds of calcium phosphate ceramics: hydr oxyapatite (Ca-10(PO4)(6)(OH)(2)), hydroxyapatite doped with manganese or z inc and a composite material of 75% hydroxyapatite and 25% beta-tricalcium phosphate (Ca-3(PO4)(2)) Cylinders (5-6 mm in diameter) of these ceramics w ere packed into holes made in the femur diaphysis of mature ovine. At 2, 4, 8, 12, 16, 20, 28, 36 and 48 weeks after the operation, bone/implant inter face was embedded in polymethylmethacrylate. We used the PIXE method (parti cle induced X-ray emission) to measure the distribution of mineral elements (Ca, P, Sr, Zn, Mn and Fe) at the bone/implant interface. At 4, 8; 16, 28 and 48 weeks after implantation we studied a biopsy of the ceramics by neut ron activation method. Then, we have a global measurement of mineral elemen ts in the biomaterial. The results showed that the resorption kinetics of h ydroxyapatite doped with zinc was faster than that of the three other bioce ramics.