An ovarian mucinous cystadenocarcinoma admired with a component of yolk sac
turner was encountered in a 71-year-old woman, the first such tumor to be
reported. The preoperative serum level of alpha-fetoprotein was elevated (5
5.6 ng/mL). A right ovarian cystic tumor, 8 cm in maximal dimension, was re
moved and found to have a solid component. Microscopically, the cystic lesi
on was a mucinous cystadenocarcinoma, whereas the solid portion was typical
yolk sac tumor with microcystic, reticular, and labyrinthine patterns. Sch
iller-Duval bodies, scattered giant cells with bizarre nuclei, and intracel
lular and extracellular hyaline globules. There was no evidence of other ge
rm cell tumor components. Yolk sac tumor showed positive reactions for alph
a-fetoprotein, carcinoembryonic antigen, and alpha-1-antitrypsin but was ne
gative for CA125, CA19-9, and human chorionic gonadotrophin. The patient di
ed of recurrent tumor 6 months postoperatively without response to combinat
ion chemotherapy.