Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: Quantitative trait locus analysis of (OLETF x BN) x OLETF

Citation
Tk. Watanabe et al., Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: Quantitative trait locus analysis of (OLETF x BN) x OLETF, GENOMICS, 58(3), 1999, pp. 233-239
Citations number
39
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENOMICS
ISSN journal
0888-7543 → ACNP
Volume
58
Issue
3
Year of publication
1999
Pages
233 - 239
Database
ISI
SICI code
0888-7543(19990615)58:3<233:GDO"AR>2.0.ZU;2-U
Abstract
To identify genetic determinants relevant to noninsulin-dependent diabetes mellitus (NIDDM), we performed a genome-wide analysis for quantitative trai t loci (QTLs) using 359 backcross progeny of the Otsuka Long-Evans Tokushim a Fatty (OLETF) rat. The OLETF strain is a well-studied animal model of obe se NIDDM, with features of hyperinsulinemia, hyperglycemia, insulin resista nce, and abundant abdominal fat. Our extensive genomic scanning with 218 ma rkers revealed nine significant QTLs, including a strong determinant of obe sity on chromosome 1 (Dmol: LOD = 13.99, for body weight). Two highly signi ficant QTLs for glucose homeostasis were found, one on chromosome 1 (Dmo4 L OD = 7.16, for postprandial glucose level) and the other on chromosome X (D mo11/Odb1: LOD = 7.81, for postprandial glucose level). These data are comp arable to results of our previous studies of the OLETF rat. (C) 1999 Academ ic Press.