SERUM CONCENTRATIONS OF SOLUBLE HLA-CLASS-I AND CD8 FORMS IN PATIENTSWITH VIRAL HEPATIC DISORDERS

Citation
M. Hagihara et al., SERUM CONCENTRATIONS OF SOLUBLE HLA-CLASS-I AND CD8 FORMS IN PATIENTSWITH VIRAL HEPATIC DISORDERS, Journal of gastroenterology, 32(3), 1997, pp. 338-343
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
ISSN journal
0944-1174
Volume
32
Issue
3
Year of publication
1997
Pages
338 - 343
Database
ISI
SICI code
0944-1174(1997)32:3<338:SCOSHA>2.0.ZU;2-F
Abstract
Soluble HLA-class I and CD8 molecules were determined by sandwich ELIS A in patients with viral-induced hepatic disorders. As a whole, the pa tients with hepatic disorders (acute hepatitis: AH; chronic hepatitis: CH: liver cirrhosis: LC; hepatocellular carcinoma: HCC) showed higher sHLA-class I and sCD8 levels than normal controls (P < 0.001). AH pat ients had the highest sHLA-class I levels (mean, 3513 +/- 2112 ng/ml), followed by CH (2896 +/- 1290 ng/ml), LC (2293 +/- 1266 ng/ml), and H CC (2221 +/- 1212 ng/ml) sCD8 levels were highest in AH, followed by H CC, LC, and CH, in that order. Among histologically defined C virus-po sitive patients, sHLA-I levels were higher in those with chronic activ e hepatitis (CAH) 2A (3802 +/- 1124 ng/ml) than in those with chronic persistent hepatitis (CPH: 2200 +/- 711 ng/ml: P < 0.01), the levels t hen decreased as the disease progressed (CAH2B, 3564 +/- 1783 ng/ml, L C, 2376 +/- 1265 ng/ml). In contrast, sCD8 values showed little differ ence among the disorders. sHLA-class I levels showed a positive correl ation with sCD8 values both in whole patients and in patients with AH (P < 0.01), but no correlation was shown, in any patients, with bioche mical parameters such as GPT and GOT. These findings, taken together, suggest that hepatic destruction is not the only cause of sHLA-class I production, but that sHLA-class I levels, together with sCD8 levels, ma!: reflect immunological activity in hepatic disorders.