D. Prim et al., Synthesis and stereochemistry of beta-aryl-beta-haloacroleins: useful intermediates for the preparation of (Z) and (E)-2-en-4-yne-carbaldehydes and for the synthesis of rubrolides, J CHEM S P2, (6), 1999, pp. 1175-1180
Physical Chemistry/Chemical Physics
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2
The synthesis of alpha-substituted beta-aryl-beta-haloacroleins by two diff
erent pathways is presented. The determination of their stereochemistry by
NOE experiments is reported for the first time. Furthermore, we describe th
e preparation of 2-en-4-ynecarbaldehydes and access to rubrolide derivative
s from beta-aryl-beta-haloacroleins.