Comparative mass spectrometric analyses of photofrin oligomers by fast atom bombardment mass spectrometry, UV and IR matrix-assisted laser desorptionionization mass spectrometry, electrospray ionization mass spectrometry and laser desorption/jet-cooling photoionization mass spectrometry

Citation
Mm. Siegel et al., Comparative mass spectrometric analyses of photofrin oligomers by fast atom bombardment mass spectrometry, UV and IR matrix-assisted laser desorptionionization mass spectrometry, electrospray ionization mass spectrometry and laser desorption/jet-cooling photoionization mass spectrometry, J MASS SPEC, 34(6), 1999, pp. 661-669
Citations number
47
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF MASS SPECTROMETRY
ISSN journal
1076-5174 → ACNP
Volume
34
Issue
6
Year of publication
1999
Pages
661 - 669
Database
ISI
SICI code
1076-5174(199906)34:6<661:CMSAOP>2.0.ZU;2-7
Abstract
Photofrin(R) (porfimer sodium) is a porphyrin derivative used in the treatm ent of a variety of cancers by photodynamic therapy. This oligomer complex and a variety of porphyrin monomers, dimers and trimers were analyzed with five different mass spectral ionization techniques: fast atom bombardment, UV and IR matrix-assisted laser desorption/ionization, electrospray ionizat ion, and laser desorption/jet-cooling photoionization. All five approaches resulted in very similar oligomer distributions with an average oligomer le ngth of 2.7 +/- 0.1 porphyrin units. In addition to the Photofrin analysis, this study provides a side-by-side comparison of the spectra for the five different mass spectrometric techniques. Copyright (C) 1999 John Wiley & So ns, Ltd.