Targeting angiogenic pathways involving tumor-stromal interaction to treatadvanced human prostate cancer

Sokoloff, MH Chung, LWK

Mh. Sokoloff et Lwk. Chung, Targeting angiogenic pathways involving tumor-stromal interaction to treatadvanced human prostate cancer, CANC METAST, 17(4), 1998, pp. 307-315

64

INGLESE

Review

Onconogenesis & Cancer Research

CANCER AND METASTASIS REVIEWS

0167-7659 → ACNP

17

4

1998

307 - 315

ISI

0167-7659(1998)17:4<307:TAPITI>2.0.ZU;2-B

Interfering with and preventing tumor angiogenesis is an attractive therape utic approach for treating cancer metastases. This commentary presents trea tment strategies that may enhance the effectiveness of anti-angiogenic ther apy by selectively targeting newly sprouting and immature vessels, inhibiti ng the production of angiogenic factors, and disrupting extracellular matri ces. We propose several clinical paradigms, including hormonal ablation, in termittent androgen suppression, chemotherapy, and radiation therapy, that 'injure' nascent vasculature and interrupt the cancer cell-stromal relation ship, thereby potentiating the efficacy of experimental anti-angiogenic age nts. These stromal-epithelial interactions play an important role in the de velopment, proliferation and dissemination of prostate cancer, as well as g uiding the processes of tumor neovascularization. Successful utilization an d targeting of tumor angiogenesis requires an increased understanding of tu mor cell-stromal cell-endothelial cell relationships, most notably the intr icate intracellular signalling cascades mediated by growth factors and the extracellular matrix.