Targeting angiogenic pathways involving tumor-stromal interaction to treatadvanced human prostate cancer

Citation
Mh. Sokoloff et Lwk. Chung, Targeting angiogenic pathways involving tumor-stromal interaction to treatadvanced human prostate cancer, CANC METAST, 17(4), 1998, pp. 307-315
Citations number
64
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER AND METASTASIS REVIEWS
ISSN journal
0167-7659 → ACNP
Volume
17
Issue
4
Year of publication
1998
Pages
307 - 315
Database
ISI
SICI code
0167-7659(1998)17:4<307:TAPITI>2.0.ZU;2-B
Abstract
Interfering with and preventing tumor angiogenesis is an attractive therape utic approach for treating cancer metastases. This commentary presents trea tment strategies that may enhance the effectiveness of anti-angiogenic ther apy by selectively targeting newly sprouting and immature vessels, inhibiti ng the production of angiogenic factors, and disrupting extracellular matri ces. We propose several clinical paradigms, including hormonal ablation, in termittent androgen suppression, chemotherapy, and radiation therapy, that 'injure' nascent vasculature and interrupt the cancer cell-stromal relation ship, thereby potentiating the efficacy of experimental anti-angiogenic age nts. These stromal-epithelial interactions play an important role in the de velopment, proliferation and dissemination of prostate cancer, as well as g uiding the processes of tumor neovascularization. Successful utilization an d targeting of tumor angiogenesis requires an increased understanding of tu mor cell-stromal cell-endothelial cell relationships, most notably the intr icate intracellular signalling cascades mediated by growth factors and the extracellular matrix.