Pilocarpine-induced cholinergic sweat secretion compared with emotional sweat secretion in atopic dermatitis

Citation
F. Kato et al., Pilocarpine-induced cholinergic sweat secretion compared with emotional sweat secretion in atopic dermatitis, BR J DERM, 140(6), 1999, pp. 1110-1113
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Dermatology,"da verificare
Journal title
BRITISH JOURNAL OF DERMATOLOGY
ISSN journal
0007-0963 → ACNP
Volume
140
Issue
6
Year of publication
1999
Pages
1110 - 1113
Database
ISI
SICI code
0007-0963(199906)140:6<1110:PCSSCW>2.0.ZU;2-M
Abstract
We studied pilocarpine-induced cholinergic sweating, emotional sweating and sympathetic reflex sweating in atopic dermatitis (AD) patients. Secreted s weat was measured both with equipment that continuously records sweat rate and with a filter paper method that measures sweat weight absorbed. Compari son of the two methods revealed that: the filter paper method underestimate d the sweat secretion in AD patients. While AD patients showed no significa nt abnormalities in emotional sweating and sympathetic reflex sweating, the duration of pilocarpine-induced sweating was prolonged. The time from the maximal sweat rate until the sweat rate fell to half of the maximal rate wa s significantly longer in AD patients than in control subjects. in contrast , the time from the beginning of sweat secretion until the maximal sweat ra te was not significantly different between AD patients and control subjects . There was no significant difference between AD patients and control subje cts in sweat volume secreted in 20 min after pilocarpine iontophoresis. In AD patients, the total sweat volume secreted after pilocarpine iontophoresi s was greater than in control subjects, although not significantly. These r esults suggest that the system of deactivation of pilocarpine-induced sweat secretion is impaired in AD patients whereas the activation system is not altered.