Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells

Citation
Jc. Medina et al., Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells, BIOORG MED, 9(13), 1999, pp. 1843-1846
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960-894X → ACNP
Volume
9
Issue
13
Year of publication
1999
Pages
1843 - 1846
Database
ISI
SICI code
0960-894X(19990705)9:13<1843:NHSITG>2.0.ZU;2-6
Abstract
In this report, we describe the synthesis of halogenated benzenesulfonamide compounds and their ability to inhibit the growth of HeLa, MCF-7 and MCF-7 /ADR tumor cells in vitro. The multidrug resistance (MDR) phenotype of cert ain cells does not affect their sensitivity to these compounds. These agent s belong to a family of compounds previously shown to bind irreversibly to cysteine-239 of beta-tubulin. Consistent with this mechanism of action, the cytotoxicities of these compounds appear to correlate with their ability t o undergo nucleophilic aromatic substitution. (C) 1999 Elsevier Science Ltd . All rights reserved.