ANTIOXIDANT STATUS AND LIPID-PEROXIDATION IN RED-BLOOD-CELLS OF P-AMINOPHENOL-TREATED RATS

Authors
Citation
M. Inal et G. Kanbak, ANTIOXIDANT STATUS AND LIPID-PEROXIDATION IN RED-BLOOD-CELLS OF P-AMINOPHENOL-TREATED RATS, Medical science research, 25(5), 1997, pp. 323-325
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, Research & Experimental
Journal title
ISSN journal
0269-8951
Volume
25
Issue
5
Year of publication
1997
Pages
323 - 325
Database
ISI
SICI code
0269-8951(1997)25:5<323:ASALIR>2.0.ZU;2-W
Abstract
Some xenobiotics and drugs lead to reactive oxygen products. Erythrocy tes have an important role in p-aminophenol (PAP) detoxification. We i nvestigated erythrocyte antioxidant status and plasma lipid peroxidati on in rats injected with PAP(200mgkg(-1)). Blood samples were obtained after 1, 24, 48, 72 and 96 h. Superoxide dismutase (SOD) activities d ecreased significantly in the PAP group within Ih while catalase (CAT) activities were lowered after 1 and 48 h. Glutathione reductase (GSSG R) activity in the PAP group was significantly high after 48, 72 and 9 6 h. Reduced glutathione (GSH) levels in the PAP group decreased after 1, 24, 48, 72 and 96 h. The plasma malondialdehyde (MDA) levels were significantly elevated in the PAP group after 24, 48, 72 and 96 h. Our findings indicate that PAP caused lipid peroxidation to increase and reduced glutathione levels to decline. SOD and CAT activities were low ered and GSSGR activities increased by PAP. Therefore, we believe that PAP may generate reactive oxygen products in erythrocytes.