Neopterin and biopterin concentrations in cerebrospinal fluid in controls less than 1 year old

Citation
Y. Sawada et al., Neopterin and biopterin concentrations in cerebrospinal fluid in controls less than 1 year old, BRAIN DEVEL, 21(4), 1999, pp. 264-267
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
BRAIN & DEVELOPMENT
ISSN journal
0387-7604 → ACNP
Volume
21
Issue
4
Year of publication
1999
Pages
264 - 267
Database
ISI
SICI code
0387-7604(199906)21:4<264:NABCIC>2.0.ZU;2-L
Abstract
Neopterin and biopterin concentrations were measured in cerebrospinal fluid (CSF) and urine samples from controls less than 1 year old. This is the fi rst time for CSF reference data for controls less than 1 year old to be rep orted. The ratio of neopterin to biopterin in CSF 0-30 days (n = 48) of age in control samples was 0.65 +/- 0.31 (SD), which was far lower than that i n urine over the same time period, 4.0 +/- 1.9 (SD), (n = 51). This finding is very important when diagnosing 6-pyruvoyltetrahydropterin synthase (PTP S) deficiency and peripheral form of PTPS deficiency in the neonatal period . Our CSF reference data for controls should be useful in the diagnosis of PTPS deficiency. (C) 1999 Elsevier Science B.V. All rights reserved.