Diversity of HLA-B17 alleles and haplotypes in East Asians and a novel Cw6allele (Cw*0604) associated with B*5701

Citation
T. Inoue et al., Diversity of HLA-B17 alleles and haplotypes in East Asians and a novel Cw6allele (Cw*0604) associated with B*5701, TISSUE ANTI, 53(6), 1999, pp. 534-544
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
TISSUE ANTIGENS
ISSN journal
0001-2815 → ACNP
Volume
53
Issue
6
Year of publication
1999
Pages
534 - 544
Database
ISI
SICI code
0001-2815(199906)53:6<534:DOHAAH>2.0.ZU;2-J
Abstract
The distribution of HLA-B17 alleles and their association with HLA-A, -C an d -DRB1 alleles were investigated in seven East Asian populations (Japanese , South Korean, Chinese-Korean, Man, Northern Han, Mon golian and Buryat po pulations), The B17 alleles were identified from genomic DNA using group-sp ecific polymerase chain reaction (PCR) followed by hybridization with seque nce-specific oligonucleotide probes (SSOP). In all of these East Asian popu lations, except Japanese and Chinese-Koreans, B*5701 was detected and stron gly associated with A*0101, Cw*0602 and DRB1*0701. In contrast, B*5801 was detected in all the seven populations and strongly associated with A*3303, Cw*0302, DRB1*0301 and DRB1*1302. The A*3303-Cw*0302-B*5801-DRB1*1302 haplo type was observed in South Korean, Chinese-Korean Buryat and Japanese popul ations, while A*3303-Cw*0302-B*5801-DRB1*0301 was predominantly observed in the Mongolian population. A similar haplotype, A*0101-Cw*0302-B*5801-DRB1* 1302, was observed in the Buryat population. A novel Cw6 allele, Cw*0604 wa s identified in the Man population, This Cw allele was observed on the hapl otype A*0101-B*5701-DRB1*0701. Thus, we confirmed, at the sequence level, t hat the common haplotypes Carrying B*5701 and B*5801 have been conserved an d shared in East Asian populations.