Bioavailability of albendazole sulphoxide after netobimin administration in sheep: effects of fenbendazole coadministration.

Citation
G. Merino et al., Bioavailability of albendazole sulphoxide after netobimin administration in sheep: effects of fenbendazole coadministration., RES VET SCI, 66(3), 1999, pp. 281-283
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
RESEARCH IN VETERINARY SCIENCE
ISSN journal
0034-5288 → ACNP
Volume
66
Issue
3
Year of publication
1999
Pages
281 - 283
Database
ISI
SICI code
0034-5288(199906)66:3<281:BOASAN>2.0.ZU;2-G
Abstract
After oral co-administration of two dosages of netobimin (7.5 and 20 mg kg( -1) with fenbendazole (1.1 mg kg(-1)) to Merino sheep, the AUC(0.infinity) of albendazole sulphoxide at the lower dosage of netobimin, was significant ly increased (75.5 per cent) from control value (34.43 +/- 7.91 versus 60.3 3 +/- 11.93 mu g h ml(-1)). The pharmacokinetic parameters MRT and T-1/2 we re also increased: 18.96 +/- 2.54 vs 26.44 +/- 4.69 h and 10.31 +/- 1.72 vs 22.28 +/- 6.75 h respectively. No data corresponding to the higher dosage of netobimin (20 mg kg(-1)) were statistically different from control value s. It is concluded that fenbendazole increases the bioavailability of alben dazole sulphoxide in sheep at the 7.5 mg kg(-1) dosage, and this may produc e a potentiated anthelmintic action.