Preparation, structural characterization, and antifungal activities of complexes of group 12 metals with 2-acetylpyridine- and 2-acetylpyridine-N-oxide-N-4-phenylthiosemicarbazones

Citation
E. Bermejo et al., Preparation, structural characterization, and antifungal activities of complexes of group 12 metals with 2-acetylpyridine- and 2-acetylpyridine-N-oxide-N-4-phenylthiosemicarbazones, Z ANORG A C, 625(6), 1999, pp. 961-968
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
ISSN journal
0044-2313 → ACNP
Volume
625
Issue
6
Year of publication
1999
Pages
961 - 968
Database
ISI
SICI code
0044-2313(199906)625:6<961:PSCAAA>2.0.ZU;2-U
Abstract
Reaction of group 12 metal dihalides in ethanolic media with 2-acetylpyridi ne N-4-phenylthiosemicarbazone (H4PL) and 2-acetylpyridine-N-oxide N-4-phen ylthiosemicarbazone (H4PLO) afforded the compounds [M(H4PL)X-2] (X = Cl, Br , M = Zn, Cd, Hg; X = I, M = Zn, Cd) (1-8), [Hg(4PL)I](2) (9) and [M(H4PLO) X2] (X = Cl, Br, I, M = Zn, Cd, Hg) (10-18). H4PL, H4PLO and their complexe s were characterized by elemental analysis and by IR and H-1 and C-13 NMR s pectroscopy (and the cadmium complexes by Cd-113 NMR spectroscopy), and H4P L, H4PLO, (5 . DMSO) and (9) were additionally studied by X-ray diffraction . H4PL is N,N,S-tridentate in all its complexes, including 9, in which it i s deprotonated, and H4PLO is in all cases O,N,S-tridentate. In all the comp lexes, the metal atoms are pentacoordinate and the coordination polyhedra a re redistorted tetragonal pyramids. In assays of antifungal activity agains t Aspergillus niger and Paecilomyces variotii, the only compound to show an y activity was [Hg(H4PLO)I-2] (18).