Chrysotile-mediated imbalance in the glutathione redox system in the development of pulmonary injury

Citation
P. Abidi et al., Chrysotile-mediated imbalance in the glutathione redox system in the development of pulmonary injury, TOX LETT, 106(1), 1999, pp. 31-39
Citations number
57
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
TOXICOLOGY LETTERS
ISSN journal
0378-4274 → ACNP
Volume
106
Issue
1
Year of publication
1999
Pages
31 - 39
Database
ISI
SICI code
0378-4274(19990520)106:1<31:CIITGR>2.0.ZU;2-6
Abstract
A significant depletion in the content of glutathione (GSH) and alteration in GSH redox system enzymes were observed in the lung of chrysotile-exposed animals (5 mg) during different developmental stages of asbestosis. In the alveolar macrophages (AM) of exposed animals, the depletion in GSH started from day 1 and reached a maximum at day 16, whereas in lung tissue the max imum depletion was observed when fibrosis has matured. It appears that cell ular GSH depletion triggers oxidative stress in the system as observed from increased thiobarbituric acid reactive substance (TBARS) production and al teration in the activities of glutathione peroxidase (GPx), glutathione red uctase (GR), glucose 6-phosphate dehydrogenase (GGPD) and glutathione S-tra nsferase (GST), the enzymes regulating oxidative tone. The depletion in GSH was also observed in red blood cells (RBC) of the exposed animals reaching a maximum when fibrosis matured. Thus the observed depletion in GSH, ascor bic acid and alteration in GSH redox system enzymes may be involved in fibr osis and carcinogenesis induced by chrysotile. (C) 1999 Published by Elsevi er Science Ireland Ltd. All rights reserved.