Molecularly imprinted polymeric membranes having EFF derivatives as a chiral recognition site

Citation
M. Yoshikawa et al., Molecularly imprinted polymeric membranes having EFF derivatives as a chiral recognition site, MACRO CH P, 200(6), 1999, pp. 1458-1465
Citations number
57
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
MACROMOLECULAR CHEMISTRY AND PHYSICS
ISSN journal
1022-1352 → ACNP
Volume
200
Issue
6
Year of publication
1999
Pages
1458 - 1465
Database
ISI
SICI code
1022-1352(199906)200:6<1458:MIPMHE>2.0.ZU;2-0
Abstract
Molecularly imprinted polymeric membranes with the tripeptide residue H-Glu (OBzl)-Phe-Phe-CH2- (EFF) were prepared during the membrane preparation (ca sting) process in the presence of a print molecule. The Ac-L-Trp imprinted polymeric membranes thus obtained showed adsorption selectivity toward Ac-L -Trp. From adsorption isotherms of Ac-Trp isomers it is seen that the chira l recognition site formed in the presence of the print molecule in the memb rane preparation process exclusively recognizes the isomer Ac-L-Trp which w as the print molecule, while the opposite isomer, Ac-D-Trp, is rigorously r ejected. The affinity constant between Ac-L-Trp and the chiral recognition site was determined to be 9.6 x 10(3) mol(-1) dm(3). Enantioselective perme ation can be attained by applying electrodialysis as a driving force. An op timum separation factor toward the L-isomer of 6.8, which corresponds to th e adsorption selectivity, can be reached.