Evaluation of the efficacy of various preparations of sodium hyaluronate in an induced equine carpitis model

Citation
Gw. White et al., Evaluation of the efficacy of various preparations of sodium hyaluronate in an induced equine carpitis model, J EQUINE V, 19(5), 1999, pp. 331-337
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
JOURNAL OF EQUINE VETERINARY SCIENCE
ISSN journal
0737-0806 → ACNP
Volume
19
Issue
5
Year of publication
1999
Pages
331 - 337
Database
ISI
SICI code
0737-0806(199905)19:5<331:EOTEOV>2.0.ZU;2-U
Abstract
A study was performed to evaluate the efficacy of three formulations of sod ium hyaluronate in an induced carpitis model. Sixteen healthy mature Quarte r Horse type horses free of lameness and carpal disease had carpitis induce d by injection of Complete Freund's Adjuvant in the left radial carpal join t, Five days after model induction the horses were assigned to four groups of four horses each and treated with either placebo, intravenous sodium hya luronate, intraarticular low molecular weight sodium hyaluronate or intraar ticular high molecular weight sodium hyaluronate, Lameness variables and synovial fluid variables were measured prior to mode l induction, just prior to treatment and across 16 weeks post treatment. Ra diographs were taken prior to model induction and at six and 16 weeks post treatment. An attempt to evaluate exercise tolerance was also made, Gross a nd histopathology were performed on one randomly selected animal from each treatment group at week 16, Results confirmed efficacy of all formulations of sodium hyaluronate in the relief of lameness as compared to placebo. Model induction led to a dramat ic decrease in synovial fluid hyaluronate concentration and mean molecular weight. All treatments restored the hyaluronate concentrations to premodel normal levels and all treatments led to an increase in model induced defici ts in mean molecular weight of synovial fluid hyaluronate; only the high mo lecular weight intraarticular preparation restored the mean molecular weigh t to premodel normal levels. Statistically significant findings in the lameness data along with trends s een in synovial fluid parameters support improved efficacy and longer durat ion of efficacy for the high molecular weight sodium hyaluronate preparatio n. Statistical weaknesses due to small group sizes and design flaws in the study prevented definitive conclusions.