Vitamin E and vascular homeostasis: implications for atherosclerosis

Citation
Jf. Keaney et al., Vitamin E and vascular homeostasis: implications for atherosclerosis, FASEB J, 13(9), 1999, pp. 965-975
Citations number
123
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Experimental Biology
Journal title
FASEB JOURNAL
ISSN journal
0892-6638 → ACNP
Volume
13
Issue
9
Year of publication
1999
Pages
965 - 975
Database
ISI
SICI code
0892-6638(199906)13:9<965:VEAVHI>2.0.ZU;2-G
Abstract
Considerable epidemiologic data suggest that dietary consumption of vitamin E reduces the incidence of cardiovascular disease. The precise mechanisms are not clear, but emerging data indicate that vitamin E has numerous activ ities that may, in part, explain its effect on vascular disease. Ln particu lar, vitamin E enhances the bioactivity of nitric oxide, inhibits smooth mu scle proliferation, and limits platelet aggregation, One common mechanism t o account for these effects of vitamin E is the inhibition of protein kinas e C stimulation, In the setting of atherosclerosis, inhibition of protein k inase C by vitamin E would be expected to maintain normal vascular homeosta sis and thus reduce the clinical incidence of cardiovascular disease.