Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas

Citation
H. Achiwa et al., Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas, CLIN CANC R, 5(5), 1999, pp. 1001-1005
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
CLINICAL CANCER RESEARCH
ISSN journal
1078-0432 → ACNP
Volume
5
Issue
5
Year of publication
1999
Pages
1001 - 1005
Database
ISI
SICI code
1078-0432(199905)5:5<1001:PSOEC2>2.0.ZU;2-4
Abstract
Recently, we demonstrated that elevated expression of cyclooxygenase 2 (COX -2) is frequently seen in a specific type of lung cancer, i.e., adenocarcin oma, and is possibly associated with its invasion and metastasis. Here, the prognostic significance of elevated COX-2 expression was evaluated in a co hort of 130 adenocarcinoma patients who had consecutively undergone potenti ally curative resections. Immunohistological examination showed the presenc e of tumor cells with markedly increased COX-2 immunoreactivity in 93 of 13 0 (72%) cases, No relationship was found between the increase in COX-2 expr ession and clinical outcomes when the entire cohort was considered (P = 0.0 99), Reasoning that the influence of the increase in COX-2 expression may h ave been obscured by the clinical and molecular pathogenetic complexities i n cases with an advanced disease, we also separately analyzed the prognosti c significance of increased COX-2 expression after stratification according to the disease stage. A significant relationship between elevated COX-2 ex pression and shortened patient survival was observed only in a cohort of pa tients with stage I disease (P = 0.034), These findings suggest that an inc rease in COX-2 expression may be clinically significant for the prognosis o f patients undergoing surgical resection of early-stage adenocarcinomas and , thus, warrant further conclusive studies involving a larger cohort.