FOG-2, a heart- and brain-enriched cofactor for GATA transcription factors

Citation
Jr. Lu et al., FOG-2, a heart- and brain-enriched cofactor for GATA transcription factors, MOL CELL B, 19(6), 1999, pp. 4495-4502
Citations number
40
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR AND CELLULAR BIOLOGY
ISSN journal
0270-7306 → ACNP
Volume
19
Issue
6
Year of publication
1999
Pages
4495 - 4502
Database
ISI
SICI code
0270-7306(199906)19:6<4495:FAHABC>2.0.ZU;2-F
Abstract
Members of the GATA family of zinc finger transcription factors have been s hown to play important roles in the control of gene expression in a variety of cell types. GATA-1, -2, and -3 are expressed primarily in hematopoietic cell lineages and are required for proliferation and differentiation of mu ltiple hematopoietic cell types, whereas GATA-4, -5, and -6 are expressed i n the heart, where they activate cardiac muscle structural genes. Friend of GATA-1 (FOG) is a multitype zinc finger protein that interacts with GATA-1 and serves as a cofactor for GATA-1-mediated transcription. FOG is coexpre ssed with GATA-1 in developing erythroid and megakaryocyte cell lineages an d cooperates with GATA-1 to control erythropoiesis, We describe a novel FOG -related factor, FOG-2, that is expressed predominantly in the developing a nd adult heart, brain, and testis, FOG-2 interacts with GATA factors, and i nteraction of GATA-4 and FOG-2 results in either synergistic activation or repression of GATA-dependent cardiac promoters, depending on the specific p romoter and the cell type in which they are tested. The properties of FOG-2 suggest its involvement in the control of cardiac and neural gene expressi on by GATA transcription factors.