Towards understanding the evolution of the human commensal yeast Candida albicans

Citation
Tj. Lott et al., Towards understanding the evolution of the human commensal yeast Candida albicans, MICROBIO-UK, 145, 1999, pp. 1137-1143
Citations number
42
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
MICROBIOLOGY-UK
ISSN journal
1350-0872 → ACNP
Volume
145
Year of publication
1999
Part
5
Pages
1137 - 1143
Database
ISI
SICI code
1350-0872(199905)145:<1137:TUTEOT>2.0.ZU;2-M
Abstract
Allelic frequencies and relationships for one dimorphic locus and three unl inked polymorphic loci have been determined for 114 unrelated isolates of C andida albicans, including 14 laboratory reference strains and 50 strains f rom each of two geographic regions. Although there was no indication of geo graphical partitioning, there were significant correlations for specific al lelic pairs among loci and little evidence that any alleles were in Hardy-W einberg equilibrium. This gives additional support for the concept that the primary mode of genetic inheritance in this species is clonal, with other intracellular genetic events playing a lesser role in the creation of genom ic diversity. Through inference of this and other known attributes of close ly related Candida species, such as sequence analysis of IS1 and the ITS2 ( internal transcribed spacer 2) region of the rDNA cistron, the deduced phyl ogeny suggests an evolutionarily recent origin for many frequently isolated strains. This finding will be of interest in the context of understanding pathogenicity and drug resistance in this human commensal yeast.