Epidemiology of risk factors for hypertension - Implications for prevention and therapy

Citation
M. Kornitzer et al., Epidemiology of risk factors for hypertension - Implications for prevention and therapy, DRUGS, 57(5), 1999, pp. 695-712
Citations number
189
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Pharmacology,"Pharmacology & Toxicology
Journal title
DRUGS
ISSN journal
0012-6667 → ACNP
Volume
57
Issue
5
Year of publication
1999
Pages
695 - 712
Database
ISI
SICI code
0012-6667(199905)57:5<695:EORFFH>2.0.ZU;2-B
Abstract
We review the present knowledge of risk factors for arterial hypertension. Both genetic and environmental factors as well as their interaction and bio logical plausibility are reviewed. Recent data confirm that the interaction of genetics with multiple environmental risk factors explains the high pre valence of hypertension in the industrialised countries. The most important modifiable environmental risk factors are high salt intake, alcohol intake , obesity and low physical activity. The role of stress in the aetiology of high blood pressure is still under i nvestigation, but recent clinical experimental and epidemiological data hav e shed light on how stress could be related to hypertension. The implications for prevention and treatment are discussed both at the pop ulation and individual levels. The population approach involves a public he alth policy aiming at modification of the major risk factors. The individua l approach involves nonpharmacological measures to prevent the development of hypertension and to treat high normal blood pressure and mild hypertensi on with no additional cardiovascular risk factors, pharmacological treatmen t of hypertension in most individuals should use agents that have been prov en to be effective in randomised controlled trials with 'hard' endpoints su ch as cardiovascular and cerebrovascular morbidity and mortality.