Increased levels of sister chromatid exchanges in military aircraft pilots

Citation
Mj. Silva et al., Increased levels of sister chromatid exchanges in military aircraft pilots, MUT RES-GTE, 441(1), 1999, pp. 129-134
Citations number
50
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
ISSN journal
1383-5718 → ACNP
Volume
441
Issue
1
Year of publication
1999
Pages
129 - 134
Database
ISI
SICI code
1383-5718(19990426)441:1<129:ILOSCE>2.0.ZU;2-C
Abstract
Sister chromatid exchanges (SCEs) were scored in lymphocytes of nine high-p erformance pilots of alphajet aircrafts and of ten control individuals from the same air base. Statistical analysis of the mean SCE count per cell in the total number of cells analyzed as well as in those having 12 or more SC Es (high-frequency cells, HFCs) revealed a significant difference between p ilots and controls, after adjusting for the effect of smoking. Analysis of the cell cycle kinetic data (replication and mitotic indices) revealed no s ignificant differences either between pilots and controls or between smoker s and nonsmokers. Previously, we reported an increase in the SCE levels in workers of the aeronautical industry exposed to noise and whole-body vibrat ion. The present results corroborate those findings and indicate that noise and whole-body vibration may cause genotoxic effects in man. (C) 1999 Else vier Science B.V. All rights reserved.