The role of intrahepatic gamma delta-T cells for liver injury induced by Salmonella infection in mouse

Citation
M. Ishigami et al., The role of intrahepatic gamma delta-T cells for liver injury induced by Salmonella infection in mouse, MICROB IMMU, 43(5), 1999, pp. 461-469
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
MICROBIOLOGY AND IMMUNOLOGY
ISSN journal
0385-5600 → ACNP
Volume
43
Issue
5
Year of publication
1999
Pages
461 - 469
Database
ISI
SICI code
0385-5600(1999)43:5<461:TROIGD>2.0.ZU;2-W
Abstract
Liver injury was induced after infection with Salmonella choleraesuis 31N-1 . In T-cell receptor-delta knockout mice, serum alanine transferase level w as significantly decreased in comparison with normal control mice after Sal monella infection. On the contrary, in vivo administration of anti-gamma de lta T-cell receptor monoclonal antibody (UC7-13D5) to stimulate gamma delta -T cells in infected mice significantly increased serum alanine transferase level but decreased bacterial growth compared with infected mice given con trol antibody (UC8; hamster IgG), These data suggest that gamma delta-T cel ls have effector activities not only for protection but also for liver inju ry during Salmonella infection.