Colon-specific delivery of budesonide with azopolymer-coated pellets: Therapeutic effects of budesonide with a novel dosage form against 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats

Citation
H. Tozaki et al., Colon-specific delivery of budesonide with azopolymer-coated pellets: Therapeutic effects of budesonide with a novel dosage form against 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats, J PHARM PHA, 51(3), 1999, pp. 257-261
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JOURNAL OF PHARMACY AND PHARMACOLOGY
ISSN journal
0022-3573 → ACNP
Volume
51
Issue
3
Year of publication
1999
Pages
257 - 261
Database
ISI
SICI code
0022-3573(199903)51:3<257:CDOBWA>2.0.ZU;2-T
Abstract
The objective of this study was to achieve colon-specific delivery of budes onide using azopolymer-coated pellets and to accelerate healing of 2,4,6-tr initrobenzenesulphonic acid sodium salt (TNBS)-induced colitis in rats. After oral administration of azopolymer-coated pellets containing budesonid e, a significant increase was observed in the therapeutic effects of the dr ug accompanied by a decrease in its systemic adverse effects when compared with oral administration in saline or rectal administration by enema. In ad dition, with the use of the colon-specific oral dosage form the dose of bud esonide could be reduced. These results suggested that azopolymer-coated pellets may be a useful dosa ge form for the colon-specific delivery of budesonide as an anti-inflammato ry steroid drug to bring about the healing of TNBS-induced colitis in rats.