H. Tozaki et al., Colon-specific delivery of budesonide with azopolymer-coated pellets: Therapeutic effects of budesonide with a novel dosage form against 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats, J PHARM PHA, 51(3), 1999, pp. 257-261
The objective of this study was to achieve colon-specific delivery of budes
onide using azopolymer-coated pellets and to accelerate healing of 2,4,6-tr
initrobenzenesulphonic acid sodium salt (TNBS)-induced colitis in rats.
After oral administration of azopolymer-coated pellets containing budesonid
e, a significant increase was observed in the therapeutic effects of the dr
ug accompanied by a decrease in its systemic adverse effects when compared
with oral administration in saline or rectal administration by enema. In ad
dition, with the use of the colon-specific oral dosage form the dose of bud
esonide could be reduced.
These results suggested that azopolymer-coated pellets may be a useful dosa
ge form for the colon-specific delivery of budesonide as an anti-inflammato
ry steroid drug to bring about the healing of TNBS-induced colitis in rats.