The major histocompatibility complex and the chemosensory signalling of individuality in humans

Citation
F. Eggert et al., The major histocompatibility complex and the chemosensory signalling of individuality in humans, GENETICA, 104(3), 1998, pp. 265-273
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENETICA
ISSN journal
0016-6707 → ACNP
Volume
104
Issue
3
Year of publication
1998
Pages
265 - 273
Database
ISI
SICI code
0016-6707(1998)104:3<265:TMHCAT>2.0.ZU;2-I
Abstract
The chemosensory identity of mice and rats is determined partly by polymorp hic genes of the major histocompatibility complex (MHC). In inbred strains of mice, as well as in seminatural populations, MHC-associated mating prefe rences selectively influence reproductive success, thus serving to promote heterozygocity in the MHC. In order to determine whether MHC-associated che mosignals are present in humans, two studies were conducted. In a first stu dy, olfactory identification of MHC-associated chemosignals was conducted o n 12 trained rats' responses to the urine odors of humans. In a second stud y, MHC-associated olfactory cues in humans were analyzed by means of gas ch romatography. The results indicate that the urine odors of humans are assoc iated with the MHC and demonstrate that the profile of volatile components in the urine odors shows some association with the MHC. Furthermore, result s show that a profile of some specific components, as well as a few ubiquit ous volatiles, constitutes MHC-associated odor signals in humans.