Cardiovascular Risk in Young Finns Study: general outline and recent developments

Citation
Hk. Akerblom et al., Cardiovascular Risk in Young Finns Study: general outline and recent developments, ANN MED, 31, 1999, pp. 45-54
Citations number
64
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
ANNALS OF MEDICINE
ISSN journal
0785-3890 → ACNP
Volume
31
Year of publication
1999
Supplement
1
Pages
45 - 54
Database
ISI
SICI code
0785-3890(199904)31:<45:CRIYFS>2.0.ZU;2-4
Abstract
The Cardiovascular Risk in Young Finns Study is a collaborative effort of a ll university departments of paediatrics and several other institutions in Finland to study the risk factors of coronary heart disease (CHD) and their determinants in children and adolescents in different parts of the country . The main cross-sectional study carried out in 1980 included 3596 3-18-yea r-old subjects. Follow-up studies have been performed in 1983, 1986, 1989 a nd 1992; in the last of these studies the subjects were 15-30 years old. Th e findings in anthropometry, obesity and blood pressure have been rather si milar to reports from other countries in Europe. However, serum cholesterol and low-density lipoprotein cholesterol concentrations were higher than in other countries, 4.83 mmol/L and 3.09 mmol/L, respectively in 1980. By 199 2 a decrease of 8% took place, probably as a result of dietary changes. Apo lipoprotein phenotypes E4E4 or E4E3 were relatively frequent (34%) in the s ample. Tracking and clustering have also been studied. Serum insulin levels predicted the clustering of the typical risk factor profile associated wit h insulin resistance syndrome. The dietary polyunsaturated to saturated fat (P/S) ratio increased from 0.26 in 1980 to 0.39 in 1992, with no significa nt changes in the total energy derived from fat. 'Hard-driving' was found t o be the psychological risk factor most consistently related to the CHD ris k factor level.