Regulation of Fc epsilon RI synthesis in human eosinophils

Citation
T. Bjerke et al., Regulation of Fc epsilon RI synthesis in human eosinophils, INT A AL IM, 118(2-4), 1999, pp. 440-442
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
ISSN journal
1018-2438 → ACNP
Volume
118
Issue
2-4
Year of publication
1999
Pages
440 - 442
Database
ISI
SICI code
1018-2438(199902/04)118:2-4<440:ROFERS>2.0.ZU;2-D
Abstract
Fc epsilon RI, the high-affinity receptor for IgE, and eosinophils are thou ght to be key components of the allergic reaction underlying asthma and rhi nitis. We provide evidence at the protein level that FceRI is expressed in human blood eosinophils, and that the synthesis of FceRI in purified human blood eosinophils is regulated by fibronectin in combination with IgE, IL-4 , both involved in allergic reactions, and by RANTES, a strong chemotactic agent for eosinophils. This provides further evidence for a regulatory effe ct of IgE on human eosinophils in allergic disease.