Effects of propranolol on the pharmacokinetics of cyclosporine after intravenous and oral administration to control rats and rats with uranyl nitrate-induced acute renal failure

Authors
Citation
Yh. Lee et Ys. Ku, Effects of propranolol on the pharmacokinetics of cyclosporine after intravenous and oral administration to control rats and rats with uranyl nitrate-induced acute renal failure, RES COM M P, 102(3), 1998, pp. 251-264
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY
ISSN journal
1078-0297 → ACNP
Volume
102
Issue
3
Year of publication
1998
Pages
251 - 264
Database
ISI
SICI code
1078-0297(199812)102:3<251:EOPOTP>2.0.ZU;2-6
Abstract
Effects of propranolol on the pharmacokinetics of cyclosporine were investi gated after intravenous and oral administration of the drugs to control rat s and rats with uranyl nitrate-induced acute renal failure (U-ARF). Effects of intravenous propranolol, 3 mg/kg, on the pharmacokinetics of intravenou s cyclosporine, 3 and 30 mg/kg, to control rats, and 30 mg/kg, to rats with U-ARF seemed to be negligible. However, the effects of orally administered propranolol, 10 mg/kg, on the area under the blood concentration-time curv e (AUC) of oral cyclosporine were significant after oral administration of cyclosporine, 10 and 100 mg/kg, to control rats. For example, the AUC of cy closporine increased significantly (33.1 versus 24.7 mu g h/ml) at cyclospo rine oral dose of 10 mg/kg, however, the value decreased significantly (167 versus 235 mu g h/ml) at cyclosporine oral dose of 100 mg/kg. Effects of o rally administered propranolol, 10 mg/kg, on the pharmacokinetics of orally administered cyclosporine, 100 mg/kg, seemed to be negligible in rats with U-ARF.