Four bis(indole) alkaloids of the topsentin class, including two new bromin
ated compounds (1 and 2), have been isolated from the sponge Spongosorites
genitrix collected from Jaeju Island, Korea. The structures of the novel co
mpounds were determined by spectroscopic methods. These compounds exhibited
moderate cytotoxicity against a human leukemia cell-line (K-562).