New bis(indole) alkaloids of the topsentin class from the sponge Spongosorites genitrix

Citation
J. Shin et al., New bis(indole) alkaloids of the topsentin class from the sponge Spongosorites genitrix, J NAT PROD, 62(4), 1999, pp. 647-649
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
62
Issue
4
Year of publication
1999
Pages
647 - 649
Database
ISI
SICI code
0163-3864(199904)62:4<647:NBAOTT>2.0.ZU;2-#
Abstract
Four bis(indole) alkaloids of the topsentin class, including two new bromin ated compounds (1 and 2), have been isolated from the sponge Spongosorites genitrix collected from Jaeju Island, Korea. The structures of the novel co mpounds were determined by spectroscopic methods. These compounds exhibited moderate cytotoxicity against a human leukemia cell-line (K-562).