Ganglioside GM1 mimicry in Campylobacter strains from sporadic infections in the United States

Citation
I. Nachamkin et al., Ganglioside GM1 mimicry in Campylobacter strains from sporadic infections in the United States, J INFEC DIS, 179(5), 1999, pp. 1183-1189
Citations number
59
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
JOURNAL OF INFECTIOUS DISEASES
ISSN journal
0022-1899 → ACNP
Volume
179
Issue
5
Year of publication
1999
Pages
1183 - 1189
Database
ISI
SICI code
0022-1899(199905)179:5<1183:GGMICS>2.0.ZU;2-F
Abstract
To determine whether GM1-like epitopes in Campylobacter species are specifi c to O serotypes associated with Guillain-Barre syndrome (GBS) or whether t hey are frequent among random Campylobacter isolates causing enteritis, 275 random enteritis-associated isolates of Campylobacter jejuni were analyzed . The isolates were collected in the United States using a cholera toxin-bi nding assay. Overall, 26.2% of the isolates were positive for the GM1-like epitope. Of the 36 different O serotypes in the sample, 21 (58.3%) containe d no strains positive for GM1, whereas in 6 serotypes (16.7%), >50% of isol ates were positive for GM1. GBS-associated serotypes were more likely to co ntain strains positive for GM1 than were non-GBS-associated serotypes (37.8 % vs. 15.1%, P = .0116). The results suggest that humans are frequently exp osed to strains exhibiting GM1-like mimicry and, while certain serotypes ma y be more likely to possess GM1-like epitopes, the presence of GM1-like epi topes on Campylobacter strains does not itself trigger GBS.