Effects of radiotherapy after hyperbaric oxygenation on malignant gliomas

Citation
K. Kohshi et al., Effects of radiotherapy after hyperbaric oxygenation on malignant gliomas, BR J CANC, 80(1-2), 1999, pp. 236-241
Citations number
41
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
0007-0920 → ACNP
Volume
80
Issue
1-2
Year of publication
1999
Pages
236 - 241
Database
ISI
SICI code
0007-0920(199904)80:1-2<236:EORAHO>2.0.ZU;2-D
Abstract
The purpose of this non-randomized trial was to evaluate the efficacy of ra diotherapy combined with hyperbaric oxygen (HBO) in patients with malignant glioma. Between 1987 and 1997, 29 patients in whom computerized tomography (CT) or magnetic resonance imaging (MRI) scans showed post-operative resid ual tumours were locally irradiated with nitrosourea-based chemotherapy, Tr eatments were consecutively combined with HBO at two institutions since 199 1 and 1993. Fifteen patients were irradiated daily after HBO, and the perio ds of time from decompression to irradiation were within 15 and 30 min in 1 1 and four patients respectively, Fourteen other patients were treated with out HBO, Tumour responses were assessed by CT or MRI scans and survival tim es were compared between the treated groups. In the HBO group, 11 of 15 pat ients (73%) showed greater than or equal to 50% tumour regression. All resp onders were irradiated within 15 min after decompression. In the non-HBO gr oup, four of 14 patients (29%) showed tumour regression. The median surviva ls in patients with and without HBO were 24 and 12 months, respectively and were significantly different (P < 0.05). No serious side-effects were obse rved in the HBO patients. In conclusion, irradiation after HBO seems to be a useful form of treatment for malignant gliomas, but irradiation should be administered immediately after decompression.