Galectin-3 expression is induced in cirrhotic liver and hepatocellular carcinoma

Citation
Dk. Hsu et al., Galectin-3 expression is induced in cirrhotic liver and hepatocellular carcinoma, INT J CANC, 81(4), 1999, pp. 519-526
Citations number
39
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF CANCER
ISSN journal
0020-7136 → ACNP
Volume
81
Issue
4
Year of publication
1999
Pages
519 - 526
Database
ISI
SICI code
0020-7136(19990517)81:4<519:GEIIIC>2.0.ZU;2-S
Abstract
Galectins are a family of beta-galactoside-binding animal lectins. In parti cular, a widely studied member galectin-3, previously designated as is an e lement of BP, CBP35, Mac-a, L-29 and L-34, has been associated with assorte d processes such as cell growth, tumor transformation and metastasis. Galec tin-3 is expressed in various tissues and organs but is significantly absen t in normal hepatocytes. However, evaluation of patient liver biopsies for galectin-3 expression resulted in the finding that hepatocellular carcinoma (HCC) frequently expressed significant levels of this lectin (76% immunohi stochemically positive). Further investigation revealed that galectin-3 exp ression in HCC is independent of whether the patient had prior hepatitis B virus infection: 14 of 18 HCC cases from HBV+ patients, and 5 of I cases fr om HBV- patients demonstrated positive galectin-3 immunohistochemistry. How ever, co-transfection studies using a galectin-3 promoter construct and an HBV-X protein (HBV-X) expression vector demonstrated that galectin-3 expres sion can occur through transactivation of the lectin promoter by HBV-X. Bas ed on presently known properties of this lectin, it is possible that deregu lated expression of galectin-3 can result in tumor transformation and invas iveness, or confer propensity for tumor cell survival. In addition, galecti n-3 was abundantly expressed in cirrhotic liver in peripheral distribution within regenerating nodules, Such galectin-3 expression in rapidly prolifer ating hepatocytes in cirrhotic liver may be a result of the high mitotic in dex. Alternatively, it is possible that proliferating cells expressing gale ctin-3 are in the process of being transformed, thus indicating an early ne oplastic event. (C) 1999 Wiley-Liss, Inc.