Tissue deposits of hydroxyethyl starch (HES): dose-dependent and time-related

Citation
C. Sirtl et al., Tissue deposits of hydroxyethyl starch (HES): dose-dependent and time-related, BR J ANAEST, 82(4), 1999, pp. 510-515
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Journal title
BRITISH JOURNAL OF ANAESTHESIA
ISSN journal
0007-0912 → ACNP
Volume
82
Issue
4
Year of publication
1999
Pages
510 - 515
Database
ISI
SICI code
0007-0912(199904)82:4<510:TDOHS(>2.0.ZU;2-7
Abstract
Tissue deposits occur after administration of plasma substitutes. After hyd roxyethyl starch (HES), deposits may last for months, causing pruritus and impairment of function. Because elimination of HES deposits has not been de monstrated in humans, we studied 26 patients, for up to 7 yr after HES admi nistration, to assess HES storage. HES dose ranged from 0.34 to 15.00 g kg( -1) body weight, and administration intervals from 1 day to 7 yr. Biopsies of the liver, muscle, spleen, intestine or skin were studied using light an d electron microscopy and immunohistochemistry. HES storage was dose-depend ent, decreased in all organs with time and was greater in patients sufferin g from pruritus. We conclude that tissue deposition of HES is transitory an d dose-dependent, with differences between subjects in severity and duratio n.