IMMUNOTERATOLOGY .1. MHC INVOLVEMENT IN THE EMBRYO RESPONSE TO TERATOGENS IN MICE

Citation
A. Torchinsky et al., IMMUNOTERATOLOGY .1. MHC INVOLVEMENT IN THE EMBRYO RESPONSE TO TERATOGENS IN MICE, American journal of reproductive immunology [1989], 34(5), 1995, pp. 288-298
Citations number
27
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Reproductive Biology",Immunology
ISSN journal
1046-7408
Volume
34
Issue
5
Year of publication
1995
Pages
288 - 298
Database
ISI
SICI code
1046-7408(1995)34:5<288:I.MIIT>2.0.ZU;2-A
Abstract
PROBLEM: The present study was carried out to evaluate an involvement of MHC-associated maternal immunoreactivity in response to environment al teratogens. METHODS: Two chemicals, cyclophosphamide (CP) and 2,3-q uinoxalinedimetanol, 1,4-dioxide (QD) were used as the reference terat ogens (RT). The response to these RT was investigated in syngeneically and allogeneically mated CBA/J and C(57)B1/6 mice. In part of C(57)B1 /6 female mice, paraaortic lymph nodes were extirpated 14 days before mating to allogeneic or syngeneic males. Twenty or 40 mg/kg of CP or 3 00 or 600 mg/kg of QD were injected on day 12 and 9 of pregnancy, acco rdingly (vaginal plug indicates day 1 of pregnancy). On day 19 of preg nancy implantation sites, resorptions, live and dead fetuses were reco rded and live fetuses were examined with methods routinely used in app lied teratology. RESULTS: Both mice strains showed equal response to t eratogens but the RT-induced effect was significantly weaker in alloge neic than syngeneic mouse combinations. Extirpation of draining lymph nodes dramatically increased the sensitivity to RT in allogeneically m ated females but failed to alter that of syngeneically mated ones. CON CLUSION: The results of this study suggest that fetomaternal MHC incom patibility exerts the favourable influence on teratological resistance of the embryo and MHC-associated immunoreactivity of ''mother-fetus'' axis is possibly responsible for this effect.