p38 kinase is activated in the Alzheimer's disease brain

Citation
K. Hensley et al., p38 kinase is activated in the Alzheimer's disease brain, J NEUROCHEM, 72(5), 1999, pp. 2053-2058
Citations number
35
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF NEUROCHEMISTRY
ISSN journal
0022-3042 → ACNP
Volume
72
Issue
5
Year of publication
1999
Pages
2053 - 2058
Database
ISI
SICI code
0022-3042(199905)72:5<2053:PKIAIT>2.0.ZU;2-W
Abstract
The p38 mitogen-activated protein kinase is a stress-activated enzyme respo nsible for transducing inflammatory signals and initiating apoptosis. In th e Alzheimer's disease (AD) brain, increased levels of phosphorylated (activ e) p38 were detected relative to age-matched normal brain. Intense phospho- p38 immunoreactivity was associated with neuritic plaques, neuropil threads , and neurofibrillary tangle-bearing neurons. The antibody against phosphor ylated p38 recognized many of the same structures as an antibody against ab errantly phosphorylated, paired helical filament (PHF) tau, although PHF-po sitive tau did not cross-react with the phospho-p38 antibody, These finding s suggest a neuroinflammatory mechanism in the AD brain, in which aberrant protein phosphorylation affects signal transduction elements, including the p38 kinase cascade, as well as cytoskeletal components.