Detection of antipneumolysin in invasive childhood pneumococcal infections

Bhaskar, M Kanungo, R Mahadevan, S Anil, P Badrinath, S

M. Bhaskar et al., Detection of antipneumolysin in invasive childhood pneumococcal infections, I J MED RES, 109, 1999, pp. 90-93

17

INGLESE

Article

Medical Research General Topics

INDIAN JOURNAL OF MEDICAL RESEARCH

0971-5916 → ACNP

109

1999

90 - 93

ISI

0971-5916(199903)109:<90:DOAIIC>2.0.ZU;2-P

Antibody levels against pneumolysin, a virulence factor in pneumococcal inf ections were evaluated by a neutralization test, using crude pneumolysin, A study population of 28 hospitalised children with culture proven pneumococ cal meningitis and pneumonia were tested for detection of antipneumolysin a ntibodies in their serum. Results were compared with age and sex matched co ntrols who were admitted with infections other than pneumococcal, Geometric mean titer (GMT) of antipneumolysin in serum of patients with pneumococcal infections showed a significant difference when compared with controls, GM T of 196.1 and 185.2 were noted in patients with meningitis and pneumonia r espectively, in contrast to a titer of 40.32 among controls. A difference o f more than 4-fold antibody titers between patients and controls was consid ered significant. Detection of antipneumolysin in serum can therefore be co nsidered as a useful laboratory investigation in diagnosing invasive pneumo coccal infections.