Synthesis and biological studies of catechol ether type derivatives as potential phosphodiesterase (PDE) IV inhibitors

Citation
Ck. Rhee et al., Synthesis and biological studies of catechol ether type derivatives as potential phosphodiesterase (PDE) IV inhibitors, ARCH PH RES, 22(2), 1999, pp. 202-207
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIVES OF PHARMACAL RESEARCH
ISSN journal
0253-6269 → ACNP
Volume
22
Issue
2
Year of publication
1999
Pages
202 - 207
Database
ISI
SICI code
0253-6269(199904)22:2<202:SABSOC>2.0.ZU;2-S
Abstract
New series of catechol ether type derivatives 5, 6 have been synthesized an d applied to biological tests. Even though it is a preliminary data, some o f our target molecules shaw the promising result against PDE IV inhibition. SAR and biological studies with synthetic compounds will be discussed in d etail.