CREUTZFELDT-JAKOB-DISEASE VIA DURAL AND CORNEAL TRANSPLANTS

Citation
Cjg. Lang et al., CREUTZFELDT-JAKOB-DISEASE VIA DURAL AND CORNEAL TRANSPLANTS, Journal of the neurological sciences, 160(2), 1998, pp. 128-139
Citations number
92
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
ISSN journal
0022-510X
Volume
160
Issue
2
Year of publication
1998
Pages
128 - 139
Database
ISI
SICI code
0022-510X(1998)160:2<128:CVDACT>2.0.ZU;2-T
Abstract
A review of all published cases of iatrogenic Creutzfeldt-Jakob diseas e (CJD) via dural (N=71) and corneal (N=4) transplants is given. All b ut three of the dural cases were obviously due to a commercial product recalled in 1996. Two of the corneal grafts were taken from patients who had died of sporadic CJD. These cases differed from CJD due to hum an growth hormone injections and the new variant. Instead, they were a kin to sporadic cases, but memory loss, disorders of higher cerebral f unctions and extrapyramidal signs were fewer, while cerebellar abnorma lities were more frequent. Progressive dysarthria and gait disorder/ga it ataxia were prominent signs during the early stages, myocloni the m ost salient feature later. A nonperiodic EEG did not contradict the di agnosis. Using current diagnostic criteria the disease was underdiagno sed ante mortem. Utmost care is needed in selecting, harvesting and ha ndling dural and corneal grafts to avoid inadvertent transmission of C JD. (C) 1998 Elsevier Science B.V. All rights reserved.