T. Ishida et al., NEW DNA POLYMORPHISMS OF HUMAN MMH OGG1 GENE - PREVALENCE OF ONE POLYMORPHISM AMONG LUNG-ADENOCARCINOMA PATIENTS IN JAPANESE/, International journal of cancer, 80(1), 1999, pp. 18-21
MMH/OGGI is an 8-hydroxyguanine-specific DNA glycosylase/AP-lyase, one
of the mutator enzymes for the excision repair of 8-hydroxyguanine. D
NA polymorphisms in human MMH/OGGI gene were newly identified and anal
yzed to examine a possible association with lung-cancer risk by a popu
lation based study. Polymorphic allele 3 in hMMH/OGGI exon I was signi
ficantly prevalent among Japanese patients with adenocarcinoma of the
lung [odds ratio (OR): 3.152, 95% confidence interval (CI): 1.266-7.84
5], indicating that the excision repair of 8-hydroxyguanine may play a
role in predisposition to lung cancer. (C) 1999 Wiley-Liss, Inc.