NEW DNA POLYMORPHISMS OF HUMAN MMH OGG1 GENE - PREVALENCE OF ONE POLYMORPHISM AMONG LUNG-ADENOCARCINOMA PATIENTS IN JAPANESE/

Citation
T. Ishida et al., NEW DNA POLYMORPHISMS OF HUMAN MMH OGG1 GENE - PREVALENCE OF ONE POLYMORPHISM AMONG LUNG-ADENOCARCINOMA PATIENTS IN JAPANESE/, International journal of cancer, 80(1), 1999, pp. 18-21
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
ISSN journal
0020-7136
Volume
80
Issue
1
Year of publication
1999
Pages
18 - 21
Database
ISI
SICI code
0020-7136(1999)80:1<18:NDPOHM>2.0.ZU;2-A
Abstract
MMH/OGGI is an 8-hydroxyguanine-specific DNA glycosylase/AP-lyase, one of the mutator enzymes for the excision repair of 8-hydroxyguanine. D NA polymorphisms in human MMH/OGGI gene were newly identified and anal yzed to examine a possible association with lung-cancer risk by a popu lation based study. Polymorphic allele 3 in hMMH/OGGI exon I was signi ficantly prevalent among Japanese patients with adenocarcinoma of the lung [odds ratio (OR): 3.152, 95% confidence interval (CI): 1.266-7.84 5], indicating that the excision repair of 8-hydroxyguanine may play a role in predisposition to lung cancer. (C) 1999 Wiley-Liss, Inc.