THE NA-COLI MUTANT LACKING THE NHAA AND NHAB PROTEINS IS APPARENT ANDCAUSED BY IMPAIRED OSMOREGULATION( AND K+ TRANSPORT DEFICIENCY OF AN ESCHERICHIA)

Citation
Ml. Verkhovskaya et al., THE NA-COLI MUTANT LACKING THE NHAA AND NHAB PROTEINS IS APPARENT ANDCAUSED BY IMPAIRED OSMOREGULATION( AND K+ TRANSPORT DEFICIENCY OF AN ESCHERICHIA), FEBS letters, 439(3), 1998, pp. 271-274
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology,"Cell Biology",Biophysics
Journal title
ISSN journal
0014-5793
Volume
439
Issue
3
Year of publication
1998
Pages
271 - 274
Database
ISI
SICI code
0014-5793(1998)439:3<271:TNMLTN>2.0.ZU;2-9
Abstract
Cells of the E, coli mutant EP432, which lacks the two Na+/H+ antiport ers, NhaA and NhaB, hale been reported to have an impaired sodium tran sport activity (Harel-Bronstein et al. (1995) J, Biol. Chem, 270, 3816 -3822). Here we report that active transport of Na+ in EP432 cells can be restored to wild-type levels, either by a high K+ concentration or by an increase in the medium osmolarity. We suggest that this mutant is primarily deficient in osmoregulation rather than in cation transpo rt per se. (C) 1998 Federation of European Biochemical Societies.