NEURONAL EXPRESSION OF FRACTALKINE IN THE PRESENCE AND ABSENCE OF INFLAMMATION

Citation
Wj. Schwaeble et al., NEURONAL EXPRESSION OF FRACTALKINE IN THE PRESENCE AND ABSENCE OF INFLAMMATION, FEBS letters, 439(3), 1998, pp. 203-207
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology,"Cell Biology",Biophysics
Journal title
ISSN journal
0014-5793
Volume
439
Issue
3
Year of publication
1998
Pages
203 - 207
Database
ISI
SICI code
0014-5793(1998)439:3<203:NEOFIT>2.0.ZU;2-X
Abstract
Fractalkine is the only as get known member of a novel class of chemok ines, Besides its novel Cys-X-X-X-Cys motif, fractalkine exhibits feat ures which have not been described for any other member of the chemoki ne family, including its unusual size (397 amino acids human, 395 mous e) and the possession of a transmembrane anchor, from which a soluble form may be released by extracellular cleavage. This report demonstrat es the abundant mRNA and fractalkine protein expression in neuronal ce lls. The neuronal expression of fractalkine mRNA is unaffected by expe rimentally induced inflammation of central nervous tissue. (C) 1998 Fe deration of European Biochemical Societies.